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Mechanisms and Pharmacology of Bone Cancer Pain – 28JUNE2022

Bone cancer pain is common in patients with advanced breast, prostate, and lung cancer as these tumors have a remarkable affinity to metastasize to bone. Bone cancer pain is very common, and patients with this type of pain may be difficult to treat.
Some models of bone cancer pain, which closely mirror the human condition, are providing insight into the mechanisms that drive bone cancer pain and guide the development of mechanism-based therapies to treat the cancer pain.

OSTEOARTHRITIS PAIN: MECHANISMS AND PHARMACOLOGY – 24JUNE2021

Osteoarthritis (OA) of the knee is a complex peripheral joint disorder. This degenerative disease involving several joint tissues is characterized by damages to the articular cartilage. Pain is the primary symptom of OA and is the driving factor for patients to seek medical help. OA-associated pain is described as dull, aching pain that persists over time, but short episodes of more intense pain, known as flares, are also experience by many individuals.

Pharmacology and mechanisms of Oxaliplatin-induced neuropathic pain – 17SEPT2020

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and challenging complication arising from treatment with many commonly used anticancer agents. In particular, oxaliplatin-induced peripheral neuropathy (OIPN) occurring during treatment requires dose reduction or cessation of treatment.

AFSSI – 02JULY2020

Learn more about our preclinical services and capabilities with a focus on Oxaliplatin-induced Peripheral Neuropathy!

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