In gastrointestinal pathologies, visceral hypersensitivity is evident as a decrease in the pain threshold. Indeed, lowered visceral sensory thresholds to colorectal distension have been found in patients suffering from Irritable Bowel Syndrome (IBS). Chemical injections or stress have been shown to induce this visceral hypersensitivity.

  • TNBS-induced colonic hypersensitivity

Colonic distension test 

  • Stress-induced hypersensitivity

Colonic distension test