A growing list of clinically relevant in vivo pain models

ANS Biotech provides a large panel of models both in acute and chronic inflammatory pain. Our studies meet the highest ethical and quality standards required for a preclinical package.

  • CARRAGEENAN-INDUCED HYPERALGESIA OR ALLODYNIA

Mechanical hyperalgesia (paw pressure test) 
Thermal hyperalgesia (plantar test)
Mechanical allodynia (electronic Von Frey test)

  • COMPLETE FREUND ADJUVANT-INDUCED HYPERALGESIA OR ALLODYNIA

Mechanical hyperalgesia (paw pressure test)
Thermal hyperalgesia (plantar test)
Mechanical allodynia (electronic Von Frey test)

  • CAPSAICIN-INDUCED ALLODYNIA

Mechanical allodynia (electronic Von Frey test)
Thermal hyperalgesia (plantar test)

  • KAOLIN-INDUCED ARTHRITIS

Gait score
Electronic Von Frey test

  • COMPLETE FREUND ADJUVANT-INDUCED MONOARTHRITIS

Mechanical hyperalgesia (paw pressure test)

  • MIA-INDUCED OSTEOARTHRITIS

Mechanical allodynia (electronic Von Frey test)

  • PARTIAL MENISCECTOMY-INDUCED OSTEOARTHRITIS

Mechanical allodynia (electronic Von Frey test)

Inflammation is part of the generic biological response of body tissues to pathogens, damaged cells or irritants. It is a protective response involving immune cells, blood vessels and molecular mediators to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and to initiate tissue repair.
Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli from the injured tissues. Chronic inflammation leads to a progressive shift in the type of cells present at the site of inflammation and is characterized by simultaneous destruction and healing of the tissue.
Among the five cardinal signs of inflammation, pain is prominent. Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibers produced by the action of inflammatory mediators and is associated with various diseases, such as osteoarthritis and rheumatoid arthritis.
Preclinical models mimicking acute and chronic inflammatory pain experienced by patients are widely and reliably used by the pharmaceutical industry to reveal the efficacy of new analgesics in such a pain area.

You may also be interested in this article: “OSTEOARTHRITIS: CURRENT SITUATION”.

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