Osteoarthritis (OA) of the knee is a complex peripheral joint disorder. This degenerative disease involving several joint tissues is characterized by damages to the articular cartilage. Pain is the primary symptom of OA and is the driving factor for patients to seek medical help. OA-associated pain is described as dull, aching pain that persists over time, but short episodes of more intense pain, known as flares, are also experience by many individuals. OA therapies focus on symptom relief and conventional pharmacological treatments show varying efficacy in patients and have inadequate safety profiles, making treatment of OA patients challenging. Rodent models of OA have been developed using different approaches (chemical, surgical and genetic) to reproduce the clinical symptoms in the patients.
During this webinar, our CSO, Laurent Diop, makes a focus on pharmacological approach in the drug discovery models and possible future treatments.