23
Oct
2019
Osteoarthritis (OA) is a degenerative disease involving several joint tissues, characterized by damages to the articular cartilage. The partial meniscectomy model presents similarities to human OA with cartilage damage, subchondral bone remodeling, and presence of osteophytes. Symptomatically, the partial meniscectomy model has been described as inducing evoked pain (tactile allodynia). The objective of this study was to evaluate the activity of different pharmacological treatments (opioid receptor agonists, nonsteroidal anti-inflammatory drug (NSAID) and local anaesthetic) on mechanical allodynia in a model of partial meniscectomy-induced OA in female rats.