Neuropathic pain originates from pathologies of the peripheral and central nervous systems. The most widely used neuropathic pain models are based on manipulations that provoke nerve damage by earlier nerve ligation or by treatment with various chemical agents.

  • Chronic Constriction Injury (CCI model)

Mechanical hyperalgesia (paw pressure test) 
Tactile allodynia (electronic Von Frey test ) 

  • Spinal Nerve Ligation (SNL model)

Tactile allodynia (electronic Von Frey test )

  • Spared Nerve Injury (SNI model)

Mechanical hyperalgesia (paw pressure test)
Tactile allodynia (electronic Von Frey test )  

  • Diabetic neuropathy (STZ model)

Mechanical hyperalgesia (paw pressure test) 
Tactile allodynia (electronic Von Frey test ) 

  • Chemotherapy-induced peripheral sensory neuropathy (Oxaliplatin model)

Cold allodynia (Paw immersion test)