Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is one of the most common disorders in gastroenterology. Alterations in local motility and hypersensitivity, along with various psychosocial factors, are major mechanistic determinants that interact to produce IBS. Digestive disorders are often associated with visceral pain in which the threshold is decreased, leading to a visceral hypersensitivity. Indeed, lowered visceral sensory thresholds to colorectal distension have been found in patients suffering from IBS, incorporating both autonomic and visceromotor responses. These same behavioral, autonomic, and motor responses induced by colonic distension have also been observed in experimental models.