Bone Cancer Pain

Chemotherapy-Induced Peripheral Neuropathy

 

Pain related to cancer may have different origins: 

Neuropathic pain directly caused by the cancer may result from compression of the nerve or direct infiltration by the growing tumour, or secondarily from changes in the neuronal milieu resulting from cancer growth or from the resulting inflammatory response. It may also result from surgery and radiotherapy.

Chemotherapy-induced pain is a direct consequence of cancer treatment with platinum salts, taxanes and vinca alkaloids. In chemotherapy, the cumulative dose-limiting toxicity is a major problem due to the painful neuropathy induced by these antineoplastic agents. When administered, these chemicals also produce neuropathies that may be used to study prevention as well as curative treatment of their subsequent neurotoxicity. Sensory neuropathies, evoking tingling sensations, paraesthesias or numbness in the distal extremities are reported in these patients. In the laboratory, bone cancer pain models can be convincingly modeled.

 

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